doi: 10.1016/j.phytochem.2011.07.018.
Epub 2011 Aug 16.
Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca
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- PMID: 21843896
- DOI: 10.1016/j.phytochem.2011.07.018
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Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca
Phytochemistry.
2011 Dec.
Abstract
The structures of a series of peroxy function containing pregnane glycosides isolated from Periploca sepium and Periploca forrestii were revised to be orthoester group bearing ones using 2D NMR spectroscopic techniques, as well as chemical transformations and X-ray crystallographic diffraction analysis. The orthoester function appears to be an essential structural feature for immunosuppressive activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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