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. 2011:3:207-11.
doi: 10.2147/IJWH.S20999. Epub 2011 Jul 20.

A randomized clinical trial to compare levonorgestrel-releasing intrauterine system (Mirena) vs trans-cervical endometrial resection for treatment of menorrhagia

Shirin Ghazizadeh  1 , Fatemeh Bakhtiari, Haleh Rahmanpour, Fatemeh Davari-Tanha, Fatemeh Ramezanzadeh
Affiliations

A randomized clinical trial to compare levonorgestrel-releasing intrauterine system (Mirena) vs trans-cervical endometrial resection for treatment of menorrhagia

Shirin Ghazizadeh et al. Int J Womens Health. 2011.

Abstract

Objective: To compare the acceptability, efficacy, adverse effects, and user satisfaction of the levonorgestrel intrauterine system (LNG-IUS) and trans-cervical resection of the endometrium (TCRE) for the treatment of menorrhagia.

Method: 104 women with menorrhagia were divided into 2 groups: 52 women had the LNG-IUS inserted and 52 underwent TCRE. Menstrual pattern, pictorial blood loss assessment chart score, adverse effects, and rates of acceptability and satisfaction, were recorded at 6 and 12 months after the procedure.

Results: After a year there were reductions of 93.9% and 88.4% in menstrual blood loss in the TCRE and LNG-IUS groups, respectively. Amenorrhea was more common in the TCRE group and spotting and systemic effects in the LNG-IUS group. Satisfaction rates of the TCRE group were higher than the LNG-IUS group (80.8% vs 69.2%), but the difference was not statistically significant.

Conclusion: Although both treatments were found to be equally effective, LNG-IUS was less invasive and can be advised for younger women with a desire to preserve fertility.

Keywords: levonorgestrel-releasing intrauterine system; menorrhagia; trans-cervical endometrial resection.

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Figures

Figure 1
Figure 1
Flow diagram of the trial. Abbreviations: LNG-IUS, levonorgestrel intrauterine system; TCRE, trans-cervical resection of the endometrium.
See this image and copyright information in PMC

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