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. 2011:2011:808524.
doi: 10.1155/2011/808524. Epub 2011 Aug 10.

PU.1 and Haematopoietic Cell Fate: Dosage Matters

Ka Sin Mak  1 , Alister P W Funnell, Richard C M Pearson, Merlin Crossley
Affiliations

PU.1 and Haematopoietic Cell Fate: Dosage Matters

Ka Sin Mak et al. Int J Cell Biol. 2011.

Abstract

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.

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Figures

Figure 1
Figure 1
Schematic showing the changing expression of PU.1 during haematopoiesis. PU.1 levels, where known, are represented by gradient bars. Gradient bars are not drawn to scale. Differentiation pathways are denoted by arrows. Abbreviations: HSC, haematopoietic stem cell; MPP, multipotent progenitor; CMP, common myeloid progenitor; CLP, common lymphoid progenitor; MEP, megakaryocyte-erythroid progenitor; GMP, granulocyte-macrophage progenitor.
See this image and copyright information in PMC

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