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Review
. 2011 Nov;32(6):461-6.
doi: 10.1007/s00292-011-1475-6.

[Molecular diagnosis of HPV infections]

[Article in German]
N Wentzensen  1
Affiliations
Review

[Molecular diagnosis of HPV infections]

[Article in German]
N Wentzensen. Pathologe. 2011 Nov.

Abstract

Carcinogenic human papillomaviruses (HPV) cause the majority of cervical cancers and other anogentical cancers. Large randomized trials have shown that HPV testing can be efficiently used for primary cervical cancer screening. Other applications include the triage of abnormal cytology results and the follow-up of women after treatment. Many assays have been developed to measure DNA, RNA, and proteins of HPV. The various tests can have very different applications. It is important to validate HPV assays before they are implemented in screening or clinical care.

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Figures

Abbildung 1
Abbildung 1. Stammbaum der Alpha-Papillomviren
Der Stammbaum fasst alle Alpha-Papillomviren zusammen, der vergroesserte Ausschnitt zeigt die Gruppen mit karzinogenen Typen. Die IARC-Karzinogentitaets-Klassifikation und der Prozentsatz in invasiven Karzinomen [11] ist fuer die einzelnen Typen angegeben.
Abbildung 2
Abbildung 2. HPV-Genom mit Zielregionen verschiedener HPV-Testverfahren
Der obere Teil der Abbildung zeigt das HPV-Genom mit offenen Leserastern und Zielregionen verschiedener HPV-Testverfahren. Der untere Teil der Abbildung zeigt die HPV-Onkogen-Transkripte, Zielregion der HPV mRNA Tests.
See this image and copyright information in PMC

Comment in

References

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    1. Cuschieri K, Wentzensen N. Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 2008;17:2536–45. - PMC - PubMed

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