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Clinical Trial
. 2011 Nov;4(11):1938-44.
doi: 10.1158/1940-6207.CAPR-10-0259. Epub 2011 Aug 16.

Methyl selenocysteine: single-dose pharmacokinetics in men

James R Marshall  1 , Clement Ip, Karen Romano, Gerald Fetterly, Marwan Fakih, Borko Jovanovic, Marjorie Perloff, James Crowell, Warren Davis, Renee French-Christy, Alexander Dew, Margerie Coomes, Raymond Bergan
Affiliations
Clinical Trial

Methyl selenocysteine: single-dose pharmacokinetics in men

James R Marshall et al. Cancer Prev Res (Phila). 2011 Nov.

Abstract

The recently published report of the SELECT evaluation of selenium and vitamin E provided strong evidence that selenium 200 μg per day in the form of selenomethionine does not protect selenium-replete men against prostate or any other cancer. This seems to refute the result of the much smaller Nutritional Prevention of Cancer (NPC) trial of selenium. Because SELECT did not test the NPC agent, it is possible that the difference between the two trials stems partly from the use of different agents: selenomethionine in SELECT, and selenized yeast in the NPC trial. One of the organic selenium forms suspected of having strong chemopreventive effects, and which may have been present in the NPC agent, is methyl selenocysteine. This study characterizes the single-dose pharmacokinetics of methyl selenocysteine.

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Figures

Figure 1
Figure 1
Mean plasma selenium concentration vs. time by dose.
Figure 2
Figure 2
Selenium Cmax* Adjusted for Baseline Levels by Dose Group
Figure 3
Figure 3
Selenium AUC Adjusted for Baseline Levels by Dose Group
Figure 4
Figure 4
Mean urine selenium concentration, by selenium dose and by time post administration
See this image and copyright information in PMC

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