Efficacy research and unanswered clinical questions

Comment

Sunita Vohra et al. JAMA. 2011.

. 2011 Aug 17;306(7):709; author reply 709-10.

doi: 10.1001/jama.2011.1150.

No abstract available

Comment on

From efficacy to effectiveness in the face of uncertainty: indication creep and prevention creep.
Djulbegovic B, Paul A. Djulbegovic B, et al. JAMA. 2011 May 18;305(19):2005-6. doi: 10.1001/jama.2011.650. JAMA. 2011. PMID: 21586716 No abstract available.

Cardiovascular clinical trials with noninferiority or equivalence designs from 2001 to 2012.
Vaduganathan M, Patel RB, Samman-Tahhan A, Kalogeropoulos AP, Georgiopoulou VV, Fonarow GC, Gheorghiade M, Butler J. Vaduganathan M, et al. Int J Cardiol. 2016 Jul 1;214:16-8. doi: 10.1016/j.ijcard.2016.03.157. Epub 2016 Mar 26. Int J Cardiol. 2016. PMID: 27055160 No abstract available.
Comparative effectiveness research: opportunities in surgical oncology.
Neuman HB, Greenberg CC. Neuman HB, et al. Semin Radiat Oncol. 2014 Jan;24(1):43-8. doi: 10.1016/j.semradonc.2013.09.003. Semin Radiat Oncol. 2014. PMID: 24314341 Review.
Emerging trends in clinical trial design.
Sessler DI, Devereaux PJ. Sessler DI, et al. Anesth Analg. 2013 Jan;116(1):258-61. doi: 10.1213/ANE.0b013e318270036d. Anesth Analg. 2013. PMID: 23264173 Review. No abstract available.
Comparative effectiveness research: relative successes.
Golub RM, Fontanarosa PB. Golub RM, et al. JAMA. 2012 Apr 18;307(15):1643-5. doi: 10.1001/jama.2012.490. JAMA. 2012. PMID: 22511694 No abstract available.
Challenges in designing comparative-effectiveness trials for antidepressants.
Leon AC. Leon AC. Clin Pharmacol Ther. 2012 Feb;91(2):165-7. doi: 10.1038/clpt.2011.208. Clin Pharmacol Ther. 2012. PMID: 22261683