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. 2011;119(1):54-6.
doi: 10.1159/000329919. Epub 2011 Aug 12.

Atherosclerosis and PTPN22: a study in coronary artery disease

P Saccucci  1 , M Banci, E Cozzoli, A Neri, A Magrini, E Bottini, F Gloria-Bottini
Affiliations

Atherosclerosis and PTPN22: a study in coronary artery disease

P Saccucci et al. Cardiology. 2011.

Abstract

Objectives: Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD).

Methods: One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs.

Results: In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07-6.72).

Conclusions: The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.

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