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. 2011 Sep 27;105(7):1061-8.
doi: 10.1038/bjc.2011.319. Epub 2011 Aug 16.

Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study

A Discacciati  1 , N Orsini, S-O Andersson, O Andrén, J-E Johansson, A Wolk
Affiliations

Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study

A Discacciati et al. Br J Cancer. .

Abstract

Background: The relationships between body mass index (BMI) during early and middle-late adulthood and incidence of prostate cancer (PCa) by subtype of the disease (localised, advanced) and fatal PCa is unclear.

Methods: A population-based cohort of 36,959 Swedish men aged 45-79 years was followed up from January 1998 through December 2008 for incidence of PCa (1530 localised and 554 advanced cases were diagnosed) and through December 2007 for PCa mortality (225 fatal cases).

Results: From a competing-risks analysis, incidence of localised PCa was observed to be inversely associated with BMI at baseline (middle-late adulthood; rate ratio (RR) for 35 kg m(-2) when compared with 22 kg m(-2) was 0.69 (95% CI 0.52-0.92)), but not at age 30. For fatal PCa, BMI at baseline was associated with a nonstatistically significant increased risk (RR for every five-unit increase: 1.12 (0.88-1.43)) and BMI at age 30 with a decreased risk (RR for every five-unit increase: 0.72 (0.51-1.01)).

Conclusion: Our results indicate an inverse association between obesity during middle-late, but not early adulthood, and localised PCa. They also suggest a dual association between BMI and fatal PCa--a decreased risk among men who were obese during early adulthood and an increased risk among those who were obese during middle-late adulthood.

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Figures

Figure 1
Figure 1
Multivariable rate ratios for BMI at age 30 years and at baseline age as predictors of incidence of localised, advanced and fatal prostate cancer. Data were fitted using a Cox proportional hazards model. BMI values at baseline age (kg m–2) and at age 30 years (kg m–2) were mutually adjusted and entered as continuous variables into the model; reference value was set at 22 kg m–2. Nonlinear relationships were modelled using second-degree fractional polynomials. Data were adjusted for age at baseline (years), total energy intake (kcal), total physical activity (<37.9, 38–40.9, 41–44.9, ⩾45 MET-h per day or missing), years of education (1–9, 9–12 or >12 years), smoking status (current, former or never smoker), family history of prostate cancer (yes, no or don’t know) and personal history of diabetes (yes or no). Dashed lines represent 95% confidence limits. Vertical lines above the curve represent cases of prostate cancer, whereas vertical lines below the curve represent non-cases of prostate cancer.
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