Degludec insulin: A novel basal insulin
- PMID: 21847448
- PMCID: PMC3152187
- DOI: 10.4103/2230-8210.83056
Degludec insulin: A novel basal insulin
Abstract
This paper reviews a novel insulin analogue, degludec, which has the potential to emerge as an ideal basal insulin. It reviews the limitations of existing basal insulin and analogues, and highlights the need for a newer molecule. The paper discusses the potential advantages of degludec, while reviewing its pharmacologic and clinical studies done so far. The paper assesses the potential role of insulin degludec and degludec plus in clinical diabetes practice.
Keywords: Basal insulin analogue; degludec; insulin analogue; second-generation insulin analogue; type 1 diabetes; type 2 diabetes.
Conflict of interest statement
References
-
- Bliss M. Resurrections in Toronto: The emergence of insulin. Horn Res. 2005;64(suppl 2):98–102. - PubMed
-
- Meneghini L, Liebl A, Abrahamson MJ. Insulin Detemir: A historical perspective on a modern basal insulin analogue. Prim Care Diabetes. 2010;4(Suppl 1):S31–42. - PubMed
-
- Bolli GB, Owens DR. Insulin glargine. Lancet. 2000;356:443–5. - PubMed
-
- Havelund S, Plum A, Ribel U, Jonassen I, Vølund A, Markussen J, et al. The mechanism of protraction of insulin detemir, a long-acting, acylated analogue of human insulin. Pharm Res. 2004;21:1498–504. - PubMed
