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Case Reports
. 2011 Nov;58(5):817-20.
doi: 10.1053/j.ajkd.2011.04.030. Epub 2011 Aug 17.

Kidney tubular toxicity of maintenance pemetrexed therapy

Ilya G Glezerman  1 , M Catherine Pietanza, Vincent Miller, Surya V Seshan
Affiliations
Case Reports

Kidney tubular toxicity of maintenance pemetrexed therapy

Ilya G Glezerman et al. Am J Kidney Dis. 2011 Nov.

Abstract

Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. Kidney function remained impaired, but stable, after discontinuation of pemetrexed therapy in all cases.

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