Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Oct;49(10):3703-6.
doi: 10.1128/JCM.01073-11. Epub 2011 Aug 17.

Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen

Kentaro Imai  1 , Tomohiko Koibuchi, Takashi Kumagai, Takuya Maeda, Yoshio Osada, Nobuo Ohta, Michiko Koga, Hitomi Nakamura, Toshiyuki Miura, Aikichi Iwamoto, Takeshi Fujii
Affiliations
Case Reports

Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen

Kentaro Imai et al. J Clin Microbiol. 2011 Oct.

Abstract

The case of a 25-year-old Japanese male who had cerebral schistosomiasis caused by Schistosoma haematobium is reported here. Although serum antibody tests showed a cross-reaction with other helminths and no ova were excreted in urine or feces, the existence of Schistosoma haematobium in the brain was confirmed by PCR analysis.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
T1-weighted MRI scan with enhancement, obtained at admission, showed tumor-like lesions in the left parietal lobe with the presence of edema.
Fig. 2.
Fig. 2.
(a) Photomicrograph showing nodular granulomas within the parenchyma of the brain containing deposits of S. haematobium ova in the center of the granulomas (hematoxylin-eosin stained; magnification, ×100). (b) Ova of S. haematobium with a characteristic prominent terminal spine (hematoxylin-eosin stained; magnification, ×400).
Fig. 3.
Fig. 3.
PCR assay for Schistosoma haematobium and S. mansoni. M, marker; lanes 1 and 5, S. mansoni DNA; lanes 2 and 6, S. haematobium DNA; lanes 3 and 7, patient DNA; lanes 4 and 8, no DNA; lanes 1 to 4, S. mansoni-specific 121-bp tandem repeat sequence; lanes 5 to 8, S. haematobium-specific DraI sequence.
See this image and copyright information in PMC

References

    1. Alves W. 1958. The distribution of schistosoma eggs in human tissues. Bull. World Health Organ. 18:1092–1097 - PMC - PubMed
    1. Braga B. P., da Costa L. B., Junior, Lambertucci J. R. 2003. Magnetic resonance imaging of cerebellar schistosomiasis mansoni. Rev. Soc. Bras Med. Trop. 36:635–636 - PubMed
    1. Carod-Artal F. J. 2008. Neurological complications of Schistosoma infection. Trans. R. Soc. Trop. Med. Hyg. 102:107–116 - PubMed
    1. Carod-Artal F. J. 2010. Neuroschistosomiasis. Expert Rev. Anti Infect. Ther. 8:1307–1318 - PubMed
    1. Chen A. W., Alam M. H., Williamson J. M., Brawn L. A. 2006. An unusually late presentation of neuroschistosomiasis. J. Infect. 53:e155–e158 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources