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Case Reports
. 2011 Dec;43(11-12):982-5.
doi: 10.3109/00365548.2011.600327. Epub 2011 Aug 19.

Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

Yasuhiro Tsuji  1 , Yoichi Hiraki, Kana Matsumoto, Akiko Mizoguchi, Shinichi Sadoh, Tsutomu Kobayashi, Yusuke Takemura, Seisaburo Sakamoto, Kunihiko Morita, Hidetoshi Kamimura, Yoshiharu Karube
Affiliations
Case Reports

Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

Yasuhiro Tsuji et al. Scand J Infect Dis. 2011 Dec.

Abstract

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

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