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. 2011 Oct;17(10):1520-4.
doi: 10.1111/j.1469-0691.2011.03600.x. Epub 2011 Aug 18.

Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina

S A Gomez  1 , F G Pasteran, D Faccone, N Tijet, M Rapoport, C Lucero, O Lastovetska, E Albornoz, M Galas; KPC Group; R G Melano, A Corso, A Petroni
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Free article

Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina

S A Gomez et al. Clin Microbiol Infect. 2011 Oct.
Free article

Abstract

The present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of bla(KPC-2) was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant geographical regions, harbouring plasmids of different incompatibility groups and bla(KPC-2) in an unusual genetic environment flanked by ISKpn8-Δbla(TEM-1) and ISKpn6-like. bla(KPC-2) was associated with IncL/M transferable plasmids; the second was the abrupt clonal spread of K. pneumoniae ST258 harbouring bla(KPC-2) in Tn4401a.

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