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Randomized Controlled Trial
. 2011 Oct;22(10):1939-45.
doi: 10.1681/ASN.2010121306. Epub 2011 Aug 18.

Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis

Rodrigo Peixoto Campos  1 , Marcelo Mazza do Nascimento, Domingos Candiota Chula, Miguel Carlos Riella
Affiliations
Randomized Controlled Trial

Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis

Rodrigo Peixoto Campos et al. J Am Soc Nephrol. 2011 Oct.

Abstract

There is growing concern about the development of antibacterial resistance with the use of antibiotics in catheter lock solutions. The use of an antibiotic that is not usually used to treat other serious infections may be an alternative that may reduce the clinical impact should resistance develop. We conducted a randomized controlled trial to compare a solution of minocycline and EDTA with the conventional unfractionated heparin for the prevention of catheter-related bacteremia in hemodialysis patients during a period of 90 d. The study included 204 incident catheters (27.8% tunneled); 14 catheters were excluded because of early dysfunction and 3 because of protocol violations. We observed catheter-related bacteremia in 19 patients in the heparin group (4.3 per 1000 catheter-days) and in 5 patients in the minocycline-EDTA group (1.1 per 1000 catheter-days; P = 0.005). We did not detect a significant difference in the rate of catheter removal for dysfunction. Catheter-related bacteremia-free survival was significantly higher in the minocycline-EDTA group than in the heparin group (P = 0.005). In conclusion, a minocycline-EDTA catheter lock solution is effective in the prevention of catheter-related bacteremia in hemodialysis patients.

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Figures

Figure 1.
Figure 1.
Randomization and follow-up.
Figure 2.
Figure 2.
Kaplan-Meier analysis of the probability that patients would remain free of catheter-related bacteremia (CRB) for all catheters.
Figure 3.
Figure 3.
Kaplan-Meier analysis of the probability that patients would remain free of catheter-related dysfunction for all catheters.
Figure 4.
Figure 4.
Kaplan-Meier analysis of the probability that patients would remain free of catheter-related bacteremia and dysfunction for all catheters.
See this image and copyright information in PMC

Comment in

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