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Case Reports
. 2011 Sep;30(9):804-6.
doi: 10.1097/INF.0b013e3182186035.

Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children

Erik Su  1 , Kelli Crowley, Joseph A Carcillo, Marian G Michaels
Affiliations
Case Reports

Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children

Erik Su et al. Pediatr Infect Dis J. 2011 Sep.

Abstract

Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

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References

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