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. 2011 Sep 26;17(40):11223-9.
doi: 10.1002/chem.201100975. Epub 2011 Aug 18.

Rose bengal-grafted biodegradable microcapsules: singlet-oxygen generation and cancer-cell incapacitation

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Rose bengal-grafted biodegradable microcapsules: singlet-oxygen generation and cancer-cell incapacitation

Xiao-Lei Wang et al. Chemistry. .

Abstract

Rose bengal-grafted chitosan (RB-CHI), synthesized through dehydration between amino and carboxyl functional groups under mild conditions, was coated onto the outer layer of preformed biodegradable microcapsules consisting of sodium alginate and chitosan. The fabricated photosensitive microcapsules were characterized by optical microscopy, scanning electron microscopy, and confocal laser scanning microscopy. The assembled materials maintained intact spherical morphology and thus showed good ability to form thin films. Electron spin resonance spectroscopy allowed direct observation of the generation of singlet oxygen ((1)O(2)) from photosensitive microcapsules under light excitation at about 545 nm. Furthermore, with increasing light radiation, the content of (1)O(2) increased, as detected by a chemical probe. In vitro cellular toxicity assays showed that RB-CHI-coated photosensitive microcapsules exhibit good biocompatibility in darkness and high cytotoxicity after irradiation, and could provide new photoresponsive drug-delivery vehicles.

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