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Case Reports
. 2012 Feb;9(1):104-7.
doi: 10.1111/j.1742-481X.2011.00846.x. Epub 2011 Aug 19.

Leg ulcers associated with Klinefelter's syndrome: a case report and review of the literature

Victoria K Shanmugam  1 , Katina C Tsagaris, Christopher E Attinger
Affiliations
Case Reports

Leg ulcers associated with Klinefelter's syndrome: a case report and review of the literature

Victoria K Shanmugam et al. Int Wound J. 2012 Feb.

Abstract

We present the case of a young man with type II diabetes, stage III chronic kidney disease, hypertension, obstructive sleep apnea and diabetes who presented to the Georgetown University Hospital Center for Wound Healing with refractory lower extremity ulcers. Autoimmune work-up was negative. However, chromosome analysis showed a genetic variant of Klinefelter's syndrome (48 XXYY). Lower extremity ulceration is a recognised complication of Klinefelter's syndrome. The pathogenesis of ulcers in this endocrinopathy is unclear, but associations with abnormalities of fibrinolysis and prothrombotic states are reported. This case emphasises the importance of considering Klinefelter's syndrome in the differential diagnosis of a sterile male patient with non healing lower extremity ulcers.

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Figures

Figure 1
Figure 1
Appearance of right leg at presentation.
Figure 2
Figure 2
Appearance of right leg after commencing androgen replacement therapy with testosterone gel.
See this image and copyright information in PMC

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