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Randomized Controlled Trial
. 2011 Aug 19:6:99.
doi: 10.1186/1749-8090-6-99.

Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass

Jie Sun  1 , Zhengnian Ding, Yanning Qian
Affiliations
Randomized Controlled Trial

Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass

Jie Sun et al. J Cardiothorac Surg. .

Abstract

The objective of this study was to investigate the effect of beta blocker on cardiac recovery and rhythm during cardiac surgeries. Sixty surgical rheumatic heart disease patients were received esmolol 1 mg/kg or the same volume of saline prior to removal of the aortic clamp. The incidence of cardiac automatic re-beat, ventricular fibrillation after reperfusion, the heart rate after steady re-beat, vasoactive drug use during weaning from bypass, the posterior parallel time and total bypass time were decreased by esmolol treatment.

In conclusion: Esmolol has a positive effect on the cardiac recovery in cardiopulmonary bypass surgeries.

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Figures

Figure 1
Figure 1
The heart recovery data after unclamping. A: The auto re-beat ratio in the control group and esmolol group. (two black triangles) P < 0.01 compared with control group. B: Ventricular fibrillation ratio in the control group and esmolol group. (two black triangles) P < 0.01 compared with control group. VF represents for Ventricular fibrillation. C: The recovery duration (time from reperfusion to steady heart beat) in the two groups. min represents minute. D: Atrial fibrillation during weaning from CPB. AF represents atrial fibrillation. E: Temporary peri-operative pacemaking use in the two groups. F: Vasoactive drug use in the two groups. (one black triangle) P < 0.05 compared with control group.
Figure 2
Figure 2
HR after unclamping. A: Heart rate after successful re-beat. (two black triangles) P < 0.01 compared with control group. HR represents heart rate and bpm represents beat per minute. B: Heart rate ten minutes after successful re-beat. HR represents heart rate and bpm represents beat per minute.
Figure 3
Figure 3
Bypass associated time. The bypass associated time between the groups. (one black triangle) P < 0.05 and (two black triangles) P < 0.01 compared with control group. The posterior parallel time means the time from releasing of aortic clamp to weaning from CPB.
See this image and copyright information in PMC

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