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. 2011 Aug 22:6:77.
doi: 10.1186/1746-1596-6-77.

Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution

Qun-Pei Yang  1 , Wen-Yan Zhang, Jian-Bo Yu, Sha Zhao, Huan Xu, Wei-Ya Wang, Cheng-Feng Bi, Zhuo Zuo, Xiao-Qing Wang, Juan Huang, Lin Dai, Wei-Ping Liu
Affiliations

Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution

Qun-Pei Yang et al. Diagn Pathol. .

Abstract

Background: The subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China.

Methods: Lymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification.

Results: From January 2000 to December 2008, a total number of 6,382 patients with lymphoma were established, of which mature B-cell neoplasms accounted for 56%, mature T- and NK-cell neoplasms occupied 26%, and precursor lymphoid neoplasms and Hodgkin lymphomas were 5% and 13%, respectively. Mixed cellularity (76%) was the major subtype of classical Hodgkin lymphoma; and the bimodal age distribution was not observed. The top six subtypes of non-Hodgkin lymphoma were as follows: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue, follicular lymphoma, precursor lymphoid neoplasms, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Extranodal lymphomas comprised about half of all cases, and most frequently involved Waldeyer's ring, gastrointestinal tract, sinonasal region and skin.

Conclusions: The lymphoid neoplasms of Southwest China displayed some epidemiologic features similar to those reported in literature from western and Asian countries, as well as other regions of China, whereas some subtypes showed distinct features. The high frequency of mature T/NK cell neoplasms and extranodal lymphomas, especially for extranodal NK/T-cell lymphoma, nasal type, is the most outstanding characteristic of this series.

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Figures

Figure 1
Figure 1
Distribution of lymphoid neoplasms by subtype, age and sex.
Figure 2
Figure 2
Distribution of histological subtypes in extranodal and nodal lymphoma.
Figure 3
Figure 3
Extranodal sites involved in non-Hodgkin lymphoma. Waldeyer's ring includes tonsil, palate, nasopharynx, pharynx and base of tongue; GI tract (gastrointestinal tract) includes stomach, small intestine and colon; Nose & sinuses includes nasal cavity and paranasal sinuses; CNS, central nervous system.
See this image and copyright information in PMC

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