Thyroid-hormone modulation of the number of beta-adrenergic receptors in rat fat-cell membranes
- PMID: 218550
- PMCID: PMC1186327
- DOI: 10.1042/bj1761007
Thyroid-hormone modulation of the number of beta-adrenergic receptors in rat fat-cell membranes
Abstract
Adipocytes from thyroidectomized rats contain 3 times less [3H]dihydroalprenolol-binding sites (beta-adrenergic receptors) than adipocytes from euthyroid animals. This alteration is not solely due to cell-size differences, but also to a thyroidectomy-induced defect in beta-adrenergic receptor density per adipocyte surface area, a defect that is furthermore corrected by tri-iodothyronine treatment.
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