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Comment
. 2011 Aug 19;43(4):500-2.
doi: 10.1016/j.molcel.2011.08.004.

Functional expansion of the tRNA world under stress

Xiang-Lei Yang  1 , Paul Schimmel
Affiliations
Comment

Functional expansion of the tRNA world under stress

Xiang-Lei Yang et al. Mol Cell. .

Abstract

Emerging mechanism for tRNA fragment-based translational regulation expands our understanding of the non-decoding roles of tRNA.

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Figures

Figure 1
Figure 1. Stress-induced tiRNA-dependent inhibition of translation initiation
Stress conditions such as oxidation and amino acid starvation induce internalization of extracellular (secreted) angiogenin. When activated, angiogenin cleaves full-length tRNAs at their anticodon loops to give 5′- and 3′-tiRNA fragments of 30–40 nucleotides. A subset of 5′-tiRNAs (5′-tiRNAAla/Cys) that contain an oligo-G motif at the 5′-end cooperates with the translational silencer YB-1 to inhibit translation initiation by recruiting eIF4E/G/A from capped mRNAs or eIF4G/A from uncapped mRNAs.
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