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. 1979 Jan 1;177(1):365-7.
doi: 10.1042/bj1770365.

6 beta-Bromopenicillanic acid inactivates beta-lactamase I

V Knott-Hunziker, B S Orlek, P G Sammes, S G Waley

6 beta-Bromopenicillanic acid inactivates beta-lactamase I

V Knott-Hunziker et al. Biochem J. .

Abstract

The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.

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