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. 2012 Jan;54(1):110-2.
doi: 10.1097/MPG.0b013e31823255c9.

Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?

Barbara Foucher  1 , Catherine Johanet, Sophie Jégo-Desplat, Marielle Sanmarco, Sylvain Dubucquoi, Sandrine Fily-Nalewajk, Nils-Olivier Olsson, Daniela Lakomy, Andrée Escande, Pascale Chrétien, Françoise Fortenfant, Alain Chevailler, Chantal André, Joëlle Goetz, René-Louis Humbel, Jean-Claude Monier, Jean Sibilia, Marie-France Taillefer, Isabelle Abreu, Nicole Fabien
Affiliations

Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?

Barbara Foucher et al. J Pediatr Gastroenterol Nutr. 2012 Jan.

Abstract

The usefulness of immumoglobulin (Ig) A antibodies to gliadin (AGA-IgA) in addition to IgA anti-endomysium and tissue transglutaminase antibodies was evaluated in 4122 children younger than 2 years with a suspicion of coeliac disease (CD). Eight percent (312/4122) displayed IgA anti-endomysium and/or IgA anti-tissue transglutaminase, whereas 2.1% (85/4122) displayed only AGA-IgA. Clinical data were obtained for 62 of 85 children with isolated AGA-IgA, and 33 children underwent a duodenal biopsy. Histologically proven CD was established for 5 patients, whereas 57 children were diagnosed to experience other diseases. The systematic detection of AGA-IgA using native gliadin conferred no additional diagnostic benefit for the diagnosis of CD in children younger than 2 years of age, except for rare cases.

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