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Review
. 1990 Feb;11(2):49-55.
doi: 10.1016/0167-5699(90)90018-5.

The costimulatory function of antigen-presenting cells

C T Weaver  1 , E R Unanue
Affiliations
Review

The costimulatory function of antigen-presenting cells

C T Weaver et al. Immunol Today. 1990 Feb.

Abstract

In addition to the expression of MHC-antigen complexes and molecules which non-specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimulatory activity for T-lymphocyte stimulation. Costimulatory molecules are essential for activation and multiplication: the presentation of antigen by cells lacking such molecules may lead to T-cell tolerance. In this review, Casey Weaver and Emil Unanue update information on interleukin 1 (IL-1), the original and best-studied costimulator, and investigate the nature of novel, as yet uncharacterized, costimulatory molecules.

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Comment in

  • Costimulatory function of APCs.
    Suttles J. Suttles J. Immunol Today. 1990 Sep;11(9):304. doi: 10.1016/0167-5699(90)90122-p. Immunol Today. 1990. PMID: 2206274 No abstract available.

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