The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients

Abstract

A total of 150 patients were included in the analysis. Through chart review, we estimated glomerular filtration rate in the first visit and, at least, 5 years later. All patients were divided into two groups: (1) metaphylaxis adherents (n = 74) and (2) metaphylaxis non-adherents (n = 76). We followed all patients for at least 5 years. The Scr percentage of patients and GFR <60 mL/min was compared between groups. Variables were compared between groups using t test, χ(2) tests, odds ratios with 95% confidence intervals. There were no differences at baseline between groups. After 5 years of follow-up, GFR was 77.9 mL/min in non-adherent-metaphylaxis group and in the adherent-metaphylaxis group was 87.3 mL/min, with p value of 0.02. After 5 years of follow-up, we had a GFR <60 mL/min in the adherent-metaphylaxis group (4.89 vs. 21.95%) with p value of 0.001 and OR = 5.36; IC-95% = 1.95-14.8. Metaphylaxis of kidney stone disease could prevent chronic kidney disease.