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. 2011 Dec;96(12):1888-90.
doi: 10.3324/haematol.2011.050617. Epub 2011 Aug 22.

The proportion of activated B-cell like subtype among de novo diffuse large B-cell lymphoma increases with age

Sylvain Mareschal, Hélène Lanic, Philippe Ruminy, Christian Bastard, Hervé Tilly, Fabrice Jardin

The proportion of activated B-cell like subtype among de novo diffuse large B-cell lymphoma increases with age

Sylvain Mareschal et al. Haematologica. 2011 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
GCB/ABC distribution with aging in DLBCL patients older than 50 years. (A) Hierarchical clustering. DLBCL were clustered according to gene expression as assessed by DASL. Genes fitting the ABC signature and genes fitting the GCB signature are indicated on the right. Patients are identified by their unique patient numbers. A color code related to age category is indicated (upper part of the HeatMap). Unsupervised hierarchical clustering was performed using ‘COR’ distances (the opposite of Pearson’s r) after Cubic Spline normalization (GenomeStudio V2009.1 software, Illumina). DLBCL diagnosis was performed according to WHO criteria. Primary mediastinal B-cell lymphomas and T-cell rich B-cell lymphomas were excluded. (B) ABC and non-ABC proportions according to age categories in a monocentric series of DLBCL. Number of patients by age category are indicated in brackets. (C) ABC and non-ABC proportions according to age in an independent series of DLBCL. Number of patients by age category are indicated in brackets.
Figure 2.
Figure 2.
Impact of the GCB/ABC molecular classification in age-matched patients. Random combinations of patients were produced from the series published by Lenzet et al. (n=350). For each patient randomly selected in the GCB group, a patient with the same age (in years) was randomly selected in the ABC group, in order to form 80GCB/ABC pairs of age-matched patients. In the 50 subseries produced, 91% of the 350 samples were selected at least once, and all Log rank P values were significative (max=0.002). (A) Overall survival in the overall population. (B) Example of survival curves obtained in a series of 80 age-matched patients.
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References

    1. Kobayashi Y, Miura K, Hojo A, Hatta Y, Tanaka T, Kurita D, et al. Charlson Comorbidity Index is an independent prognostic factor among elderly patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2011;137(7):1079–84. - PMC - PubMed
    1. Peyrade F, Jardin F, Thieblemont C, Thyss A, Emile JF, Castaigne S, et al. Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2011;12(5):460–8. - PubMed
    1. Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, et al. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med. 2008;359(22):2313–23. - PMC - PubMed
    1. Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937–47. - PubMed
    1. Ruminy P, Etancelin P, Couronné L, Parmentier F, Rainville V, Mareschal S, et al. The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma. Leukemia. 2011;25(4):681–8. - PubMed