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. 2011 Nov;55(11):5358-61.
doi: 10.1128/AAC.00690-11. Epub 2011 Aug 22.

Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France

Elodie Blanchard  1 , Olivier Lortholary, Karine Boukris-Sitbon, Marie Desnos-Ollivier, Françoise Dromer, Didier Guillemot; French Mycosis Study Group
Collaborators, Affiliations

Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France

Elodie Blanchard et al. Antimicrob Agents Chemother. 2011 Nov.

Abstract

Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68-16.35) and with an age of ≤ 65 years (OR = 3.27; 95% CI, 1.26-8.50).

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Figures

Fig. 1.
Fig. 1.
Flow chart of the process used to match cases (infections with CRSC) with controls (infections with CSC) at a 1:2 ratio for cases and controls occurring within the same 1-year period.
See this image and copyright information in PMC

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