Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011;76(4):273-7.
doi: 10.1159/000330005. Epub 2011 Aug 22.

Constitutional advancement of growth is associated with early puberty in girls

Anastasios Papadimitriou  1 , George Kanakis, Konstantinos Douros, Dimitrios T Papadimitriou, Anastasios H Boutsiadis, Polyxeni Nicolaidou, Andreas Fretzayas
Affiliations

Constitutional advancement of growth is associated with early puberty in girls

Anastasios Papadimitriou et al. Horm Res Paediatr. 2011.

Abstract

Background: Constitutional advancement of growth (CAG) is the growth pattern of early growth acceleration that has been shown to be characteristic in girls with idiopathic precocious puberty (IPP). The aim of this study was to examine the growth pattern of girls with early puberty compared to girls with IPP.

Methods: We studied the growth pattern, from birth to presentation, of 61 girls with early puberty, of 40 girls with IPP and of 100 healthy girls with normal pubertal onset that served as controls.

Results: Height SDS (HSDS) at presentation was significantly different among the 3 groups (p < 0.001). Girls with early puberty were shorter than girls with IPP (HSDS 0.63 ± 1.09 vs. 0.98 ± 0.95, respectively, p < 0.001) and taller than control girls (HSDS 0.05 ± 0.94, p < 0.05). By comparing the linear growth pattern from birth to presentation, pairwise comparisons showed that it differed significantly between early puberty and control (p < 0.001) as well as between IPP and control girls (p < 0.001), whereas the difference between girls with IPP and early puberty was not significant (p = 0.09).

Conclusion: Girls with early puberty present the pattern of CAG suggesting that IPP lies at the extreme of the distribution of the normal timing of puberty onset.

PubMed Disclaimer