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. 2011 Sep;7(9):976-81.
doi: 10.4161/hv.7.9.16407. Epub 2011 Sep 1.

Anti-angiogenesis immunotherapy

Jonathan D Schoenfeld  1 , Glenn Dranoff
Affiliations

Anti-angiogenesis immunotherapy

Jonathan D Schoenfeld et al. Hum Vaccin. 2011 Sep.

Abstract

Tumors stimulate angiogenesis to meet increasing nutrient and oxygen demands. In addition to their role in vascular remodeling, pro-angiogenic cytokines and effector cells contribute to an immune-inhibitory environment associated with advanced malignancies. Despite the critical role of angiogenesis in tumor growth and dissemination, most anti-angiogenic cancer therapies have had only limited success selectively targeting one of the many factors implicated in this process. Similarly, the effectiveness of tumor immunotherapies has been limited by tumor-mediated escape mechanisms and immune suppression. By combining the two strategies, however, anti-angiogenic immunotherapy offers the possibility to more robustly inhibit tumor angiogenesis and simultaneously impact the immune-inhibitory effects of the pro-angiogenic tumor milieu. These potential synergies make the combination of immunotherapy and anti-angiogenic treatment a promising avenue for future research.

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Figure 1
Figure 1
combined use of tumor immunotherapy and anti-angiogenic therapy may help overcome barriers to successful tumor eradication.
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