Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2011 Aug 23;3(9):692-5.
doi: 10.1038/nchem.1121.

Getting physical to fix pharma

Patrick R Connelly, T Minh Vuong, Mark A Murcko
Editorial

Getting physical to fix pharma

Patrick R Connelly et al. Nat Chem. .

Abstract

Powerful technologies allow the synthesis and testing of large numbers of new compounds, but the failure rate of pharmaceutical R&D remains very high. Greater understanding of the fundamental physical chemical behaviour of molecules could be the key to greatly enhancing the success rate of drug discovery.

PubMed Disclaimer

References

    1. J Med Chem. 2009 Mar 12;52(5):1231-46 - PubMed
    1. Expert Opin Investig Drugs. 2007 Jul;16(7):1037-58 - PubMed
    1. Nat Methods. 2010 Apr;7(4):319-23 - PubMed
    1. Angew Chem Int Ed Engl. 2011 Feb 7;50(6):1242-58 - PubMed
    1. Nat Rev Drug Discov. 2010 Mar;9(3):203-14 - PubMed

Publication types

LinkOut - more resources