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Review
. 2011 Oct;11(12):1002-8.
doi: 10.2174/138955711797247752.

Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives

L Stavitskaya  1 , A Coop
Affiliations
Review

Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives

L Stavitskaya et al. Mini Rev Med Chem. 2011 Oct.

Abstract

The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.

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