[Current status of knowledge of the effect of benzene. Impairment of blood and hemopoiesis]

Abstract

The alteration of the hemopoiesis is the result of a lot of particular cases. The inhibition of the microtubuli assembly suppresses the cell division because of the missing of the spindle formation. This is associated with an inhibition of the supporting stroma of the bone marrow and of the different lymphocytes complicated with a depression of colony stimulating factors. There is also an alkylation of the nuclear and mitochondrial RNA, DNA and proteins together with an inactivation of the DNA polymerase. Immunosuppressive effects are associated with autoimmune events. Benzene is classified as a weak carcinogenic initiator.