Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct;249(10):1439-48.
doi: 10.1007/s00417-011-1764-z. Epub 2011 Aug 25.

Promises of stem cell therapy for retinal degenerative diseases

Ian Yat-Hin Wong  1 , Ming-Wai Poon, Rosita Tsz-Wai Pang, Qizhou Lian, David Wong
Affiliations
Review

Promises of stem cell therapy for retinal degenerative diseases

Ian Yat-Hin Wong et al. Graefes Arch Clin Exp Ophthalmol. 2011 Oct.

Abstract

With the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and ultimately cure retinal degeneration, there are several important challenges which need to be overcome before stem cell technology can be applied widely in clinical settings. In this review, different types of donor cell origins used in retinal treatments, potential target cell types for therapy, methods of stem cell delivery to the eye, assessments of potential risks in stem cell therapy, as well as future developments of retinal stem cells therapy, will be discussed.

PubMed Disclaimer

References

    1. Sohocki MM, Daiger SP, Bowne SJ, Rodriquez JA, Northrup H, Heckenlively JR, Birch DG, Mintz-Hittner H, Ruiz RS, Lewis RA, Saperstein DA, Sullivan LS. Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies. Hum Mutat. 2001;17:42–51. doi: 10.1002/1098-1004(2001)17:1<42::AID-HUMU5>3.0.CO;2-K. - DOI - PMC - PubMed
    1. Klein BE. Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol. 2007;14:179–183. doi: 10.1080/09286580701396720. - DOI - PubMed
    1. Ah-Fat FG, Sharma MC, Majid MA, McGalliard JN, Wong D. Trends in vitreoretinal surgery at a tertiary referral centre: 1987 to 1996. Br J Ophthal. 1999;83:396–398. doi: 10.1136/bjo.83.4.396. - DOI - PMC - PubMed
    1. Degenring RF, Cordes A, Schrage NF (2010) Autologous translocation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Acta Ophthalmol Mar 19. [Epub ahead of print] - PubMed
    1. Enzmann V, Yolcu E, Kaplan HJ, Ildstad ST. Stem cells as tools in regenerative therapy for retinal degeneration. Arch Ophthalmol. 2009;127:563–571. doi: 10.1001/archophthalmol.2009.65. - DOI - PMC - PubMed

Publication types

LinkOut - more resources