Intracellular pathogens and CD8(+) dendritic cells: dangerous liaisons
- PMID: 21867923
- DOI: 10.1016/j.immuni.2011.08.003
Intracellular pathogens and CD8(+) dendritic cells: dangerous liaisons
Abstract
CD8(+) dendritic cells comprise a distinct cell type whose function is unclear. In this issue of Immunity, Mashayekhi et al. (2011) show these cells are essential for protection against the parasite Toxoplasma, but Edelson et al. (2011) show they are hijacked by Listeria during initial spreading.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.Immunity. 2011 Aug 26;35(2):236-48. doi: 10.1016/j.immuni.2011.06.012. Immunity. 2011. PMID: 21867927 Free PMC article.
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CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.Immunity. 2011 Aug 26;35(2):249-59. doi: 10.1016/j.immuni.2011.08.008. Immunity. 2011. PMID: 21867928 Free PMC article.
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