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Comment
. 2011 Aug 26;35(2):156-7.
doi: 10.1016/j.immuni.2011.08.005.

Value added: neural progenitor cells suppress inflammation and autoimmunity

Amit Awasthi  1 , Vijay K Kuchroo
Affiliations
Comment

Value added: neural progenitor cells suppress inflammation and autoimmunity

Amit Awasthi et al. Immunity. .

Abstract

Neural progenitor cells (NPCs) can repair damaged myelin in neurodegenerative diseases. In this issue of Immunity, Cao et al. (2011) report that NPCs also produce the cytokine LIF, which suppresses Th17 cell-driven inflammation and autoimmunity by upregulating the protein Socs3.

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Figures

Figure 1
Figure 1
NPC-derived leukemia inhibitory factor (LIF) induced ERK-1 and 2 dependent activation of Socs3 expression. Overexpression of Socs3 by LIF attenuates the activation of STAT3, which in turn suppress IL-17 production.
See this image and copyright information in PMC

Comment on

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