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. 2011 Nov 15;184(10):1107-13.
doi: 10.1164/rccm.201106-0995PP. Epub 2011 Aug 25.

Tuberculosis drug development: ensuring people living with HIV are not left behind

Anne F Luetkemeyer  1 , Haileyesus Getahun, Gabriel Chamie, Christian Lienhardt, Diane V Havlir
Affiliations

Tuberculosis drug development: ensuring people living with HIV are not left behind

Anne F Luetkemeyer et al. Am J Respir Crit Care Med. .

Abstract

An unprecedented number of new tuberculosis (TB) medications are currently in development, and there will be great pressure to deploy these new drugs among all populations after their efficacy is demonstrated. People living with HIV experience a large burden of TB and have a particularly pressing need for TB treatments that are shorter and less toxic. In addition, all people living with HIV now require antiretroviral therapy during TB treatment. A roadmap of the research, programmatic, and regulatory considerations includes the following: (1) inclusion of people living with HIV early in clinical trials for treatment and prevention using new TB medications, (2) prioritization of key studies of HIV-TB drug interactions and interactions between new TB agents, and (3) optimization of clinical trial infrastructure, laboratory capacity, and drug susceptibility testing.

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Figures

Figure 1.
Figure 1.
Timeline for inclusion of people living with HIV in TB drug development. ART = antiretroviral therapy; EBA = early bactericidal activity study; SSCC = serial sputum colony counting study; TB = tuberculosis. Adapted from Ginsberg and colleagues (33).
See this image and copyright information in PMC

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