[Modification of the response of nude mice to mouse hepatitis virus by transfer of heterozygote splenic cells]

Abstract

The course of infection with low-virulence mouse hepatitis virus in nude mice was modified by transfer of sensitized or non-sensitized heterozygous spleen cells after the infection had been established. Infected nude mice having received the transfer of heterozygous spleen cells seem to have more severe signs of illness at early stage of infection than those without the heterozygous cell transfer, while they resisted against the infection.