[Use of mathematical models in study of nitric oxide, myoglobin and cell oxygen regimen]

Abstract

The influence ofnanomolar concentrations of NO on oxygen regimen of muscle cells was investigated. The intracellular distribution of oxygen consumption rates, pO2, NO and myoglobin was calculated by mathematical modeling of diffusion reactions of O2, NO and myoglobin in the muscle cell. The diffusion of O2, and NO from blood vessel surface into cell was taken into account. According to calculations, NO roughly regulates the oxygen regimen of cell, because it increases the tissue pO2 level by inhibition of mitochondria activity in the whole cell space. The presence ofmyoglobin is capable potentially to modulate the influence of NO on oxygen regimen. Myoglobin not only contributes to tissue O2 supply, but it can locally affect the NO concentration. Acting as an NO scavenger under normoxia and as an NO producer under hypoxia, myoglobin together with NO can provide fine adjustment of muscle oxygen regimen via an increase in tissue pO, and elimination a mismatch between oxygen supply and demand.