Review
[Amiodarone and thyroid: the Janus effect]
[Article in
French]
Affiliations
- PMID: 2187219
Item in Clipboard
Review
[Amiodarone and thyroid: the Janus effect]
[Article in
French]
Rev Med Brux.
1990 Apr.
Erratum in
- Rev Med Brux 1990 Sep;11(7):315
Abstract
Iodide released from Amiodarone during a chronic treatment is 100 x higher than food iodide intake. Thyroid adaptation allows normal function but over-adaptation leads to hypothyroidism and hypo-adaptation to thyrotoxicosis. Thyrotoxicosis may also result from follicular disruption. Amiodarone inhibits 5' deiodinase type I and II and hence increases serum T4 and (transiently) TSH and decreases serum T3 concentrations. Perchlorate and corticoids may be useful in the treatment of thyrotoxicosis.
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