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. 2011 Aug;27(2):233-42.
doi: 10.1016/j.cveq.2011.04.003. Epub 2011 Jun 16.

Embryonic stem cells and iPS cells: sources and characteristics

Catherine H Hackett  1 , Lisa A Fortier
Affiliations

Embryonic stem cells and iPS cells: sources and characteristics

Catherine H Hackett et al. Vet Clin North Am Equine Pract. 2011 Aug.

Abstract

The field of regenerative medicine research is rapidly expanding. One area of interest to equine researchers is the possibility of isolating or generating pluripotent cells, capable of producing differentiated cell types derived from all 3 primary germ layers. Reports of equine embryonic stem-like (ES) cell isolation can be found in the literature. Other groups are working to produce equine-induced pluripotent stem (iPS) cells. This article summarizes the essential features needed to characterize a cell type as pluripotent, specific challenges in using the horse as a model organism for pluripotent cell generation, and current and upcoming clinical trials using ES/iPS cells.

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Figures

Figure 1
Figure 1
Putative equine iPS cells on a primary transformation plate (A–C) and after culture for 13 passages (D). The putative equine iPS colonies are morphologically similar to human iPS cell colonies (A, D) and are positive for alkaline phosphatase staining (B, C). (Courtesy of Lauren V. Schnabel, DVM, Ithaca, NY.)
See this image and copyright information in PMC

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