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Comment
. 2011 Sep 6;108(36):14711-2.
doi: 10.1073/pnas.1111230108. Epub 2011 Aug 25.

Olfactory habituation: fresh insights from flies

David L Glanzman  1
Affiliations
Comment

Olfactory habituation: fresh insights from flies

David L Glanzman. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Cellular model of olfactory habituation in Drosophila based on the work of Ramaswami and colleagues (4, 5). Prolonged exposure to an odor produces sustained excitation of olfactory receptor neurons (ORNs), and, in turn, of the local neuron (LN). Repeated firing of the LN activates the Ca2+-sensitive adenylyl cyclase (AC) rutabaga within the LN. When stimulated, the LN coreleases the inhibitory transmitter GABA and the excitatory transmitter glutamate from its terminals. The GABA binds to GABA receptors, and the glutamate binds to NMDARs, in the postsynaptic membrane of the projection neuron (PN). The depolarization of the PN produced by ORN input, together with the released glutamate, opens NMDAR channels, resulting in an influx of Ca2+ into the PN dendrites. The elevated postsynaptic intracellular Ca2+ stimulates local protein synthesis within the PN, and the translational products, possibly together with the elevated intracellular Ca2+, trigger retrograde signaling. In addition, rutabaga activity, possibly in conjunction with the NMDAR-dependent retrograde signal, stimulates the transcription factor cAMP response element binding protein (CREB) in the nucleus of the LN. CREB-dependent transcription produces long-term changes in the LN, including structural changes.
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