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. 2011 Nov;55(11):5018-21.
doi: 10.1128/AAC.00536-11. Epub 2011 Aug 29.

Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009

Sarah P Hammond  1 , Lindsey R Baden, Francisco M Marty
Affiliations

Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009

Sarah P Hammond et al. Antimicrob Agents Chemother. 2011 Nov.

Abstract

Mortality due to mucormycosis is high. We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009. Thirty patients were diagnosed with probable or proven mucormycosis during the study. Twenty-six were diagnosed premortem, and most were treated with liposomal amphotericin B single-agent antifungal therapy initially. While the initial antifungal and surgical treatment approach remained stable throughout the study period, 6-week mortality significantly declined over time (67% in 2001 to 2003 versus 45% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.04]), as did 12-week mortality (78% in 2001 to 2003 versus 55% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.01]).

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References

    1. Chamilos G., Lewis R. E., Kontoyiannis D. P. 2008. Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis. Clin. Infect. Dis. 47:503–509 - PubMed
    1. De Pauw B., et al. 2008. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin. Infect. Dis. 46:1813–1821 - PMC - PubMed
    1. Greenberg R. N., et al. 2006. Posaconazole as salvage therapy for zygomycosis. Antimicrob. Agents Chemother. 50:126–133 - PMC - PubMed
    1. Hammond S. P., et al. 2011. Molecular Methods to Improve the Diagnosis and Identification of Mucormycosis. J. Clin. Microbiol. 49:2151–2153 - PMC - PubMed
    1. Hammond S. P., Koo S., Baden L. R., Marty F. M. 2009. Abstr. 49th Intersci. Conf. Antimicrob. Agents Chemother., abstr. M-1050 - PMC - PubMed

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