Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:891342.
doi: 10.1155/2011/891342. Epub 2011 Aug 17.

Low- and high-tech approaches to control Plasmodium parasite transmission by anopheles mosquitoes

Chris M Cirimotich  1 , April M Clayton, George Dimopoulos
Affiliations

Low- and high-tech approaches to control Plasmodium parasite transmission by anopheles mosquitoes

Chris M Cirimotich et al. J Trop Med. 2011.

Abstract

Current efforts have proven inadequate to stop the transmission of Plasmodium parasites, and hence the spread of malaria, by Anopheles mosquitoes. Therefore, a novel arsenal of strategies for inhibiting Plasmodium infection of mosquitoes is urgently needed. In this paper, we summarize research on two approaches to malaria control, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high-tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.

PubMed Disclaimer

References

    1. Cirimotich CM, Dong Y, Clayton AM, et al. Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae . Science. 2011;332(6031):p. 855. - PMC - PubMed
    1. Gonzales-Ceron L, Santillan F, Rodriguez MH, Mendez D, Hernandez-Avila JE. Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development. Journal of Medical Entomology. 2003;40(3):371–374. - PubMed
    1. Lindh JM, Terenius O, Faye I. 16S rRNA gene-based identification of midgut bacteria from field-caught Anopheles gambiae sensu lato and A. funestus mosquitoes reveals new species related to know insect symbionts. Applied and Environmental Microbiology. 2005;71(11):7217–7223. - PMC - PubMed
    1. Pumpuni CB, Beier MS, Nataro JP, Guers LD, Davis JR. Plasmodium falciparum: inhibition of sporogonic development in Anopheles stephensi by gram-negative bacteria. Experimental Parasitology. 1993;77(2):195–199. - PubMed
    1. Pumpuni CB, Demaio J, Kent M, Davis JR, Beier JC. Bacterial population dynamics in three anopheline species: the impact on Plasmodium sporogonic development. American Journal of Tropical Medicine and Hygiene. 1996;54(2):214–218. - PubMed

LinkOut - more resources