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. 2011:2011:475216.
doi: 10.1155/2011/475216. Epub 2011 Aug 25.

Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats

Marcela Alejandra Vazquez-Prieto  1 , Cecilia Rodriguez Lanzi, Carina Lembo, Claudio Rómulo Galmarini, Roberto Miguel Miatello
Affiliations

Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats

Marcela Alejandra Vazquez-Prieto et al. J Nutr Metab. 2011.

Abstract

This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables.

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Figures

Figure 1
Figure 1
Plasma TBARS from C, F, F+T, F+G, and F+O groups. Values are expressed as mean ± SEM, (n = 6); bars with different superscripts differ, P < 0.05.
Figure 2
Figure 2
Aortic NAD(P)H oxidase activity C, F, F+T, F+G, and F+O groups (n = 6 rats per groups). Values are expressed as mean ± SEM, (n = 6); bars with different superscripts differ, P < 0.05.
Figure 3
Figure 3
Heart endothelial nitric oxide synthase (eNOS) activity from C, F, F+T, F+G, and F+O groups. Values are expressed as mean ± SEM, (n = 6); bars with different superscripts differ, P < 0.05.
Figure 4
Figure 4
Vascular cell adhesion molecule-1 (VCAM-1) protein expression in vascular mesenteric tissue assessed by western blotting from C, F, F+T, F+G, and F+O groups. Values are expressed as mean ± SEM, (n = 4); bars with different superscripts differ, P < 0.05.
Figure 5
Figure 5
Immunohistochemistry analysis of VCAM-1 in endothelial cells of vascular mesenteric tissue from C, F, F+T, F+G, and F+O groups (n = 4). Each photo shows an enlarged image. The arrows indicate the VCAM-1 expression in the endothelium: magnification ×400.
See this image and copyright information in PMC

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