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. 2011:2011:293808.
doi: 10.4061/2011/293808. Epub 2011 Aug 16.

A review on current osteoporosis research: with special focus on disuse bone loss

Roy Yuen-Chi Lau  1 , Xia Guo
Affiliations

A review on current osteoporosis research: with special focus on disuse bone loss

Roy Yuen-Chi Lau et al. J Osteoporos. 2011.

Abstract

Osteoporosis is a multifactorial skeletal disorder characterized by decreased bone mass and deteriorated microarchitecture that lead to increased risk of fracture. The disuse osteoporosis refers to bone mass decrements under conditions of decreased mechanical loading, including decreased ground force reaction, muscular contraction, and microgravity-related bone loss in astronauts after space flights. Although there are many effective treatments available for primary osteoporosis, there is a lack of effective treatments for disuse osteoporosis. This is because that the aetiology, pathophysiology, and resultant pathology of disuse osteoporosis differ from those of primary osteoporosis. The objective of this paper is to examine the unique pathology and underlying pathophysiology of disuse osteoporosis.

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Figures

Figure 1
Figure 1
Transition electron micrograph of osteoclast-osteoblast contact in mouse tibial bone marrow (14-week-old male). Arrowheads indicate a contact surface between osteoclasts (OC) and osteoblasts (OB). Scale bar, 5 μm [18].
Figure 2
Figure 2
Regulatory mechanisms of osteoclastogenesis [22].
Figure 3
Figure 3
Role of canonical Wnt signaling in the control of osteoblastogenesis.
See this image and copyright information in PMC

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