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. 2011;66(7):1203-8.
doi: 10.1590/s1807-59322011000700014.

Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer

Lucas Leite Cunha  1 , Alfio Jose Tincani, Ligia Vera Montalli da Assumpção, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward
Affiliations

Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer

Lucas Leite Cunha et al. Clinics (Sao Paulo). 2011.

Abstract

Objectives: The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis.

Methods: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism.

Results: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases.

Conclusions: We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.

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References

    1. Pisanu A, Piu S, Cois A, Uccheddu A. Coexisting Hashimoto's thyroiditis with differentiated thyroid cancer and benign thyroid diseases: indications for thyroidectomy. Chir Ital. 2003;55:365–72. - PubMed
    1. Segal K, Ben-Bassat M, Avraham A, Har-El G, Sidi J. Hashimoto's thyroiditis and carcinoma of the thyroid gland. Int Surg. 1985;70:205–9. - PubMed
    1. Loh KC, Greenspan FS, Dong F, Miller TR, Yeo PP. Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 1999;84:458–63. 10.1210/jc.84.2.458 - DOI - PubMed
    1. Ugolini C, Basolo F, Proietti A, Vitti P, Elisei R, Miccoli P, et al. Lymphocyte and immature dendritic cell infiltrates in differentiated, poorly differentiated, and undifferentiated thyroid carcinoma. Thyroid. 2007;17:389–93. 10.1089/thy.2006.0306 - DOI - PubMed
    1. Arif S, Blanes A, Diaz-Cano SJ. Hashimoto's thyroiditis shares features with early papillary thyroid carcinoma. Histopathology. 2002;41:357–62. 10.1046/j.1365-2559.2002.01467.x - DOI - PubMed

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