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Meta-Analysis
. 2011 Nov;137(11):1661-7.
doi: 10.1007/s00432-011-1045-6. Epub 2011 Aug 30.

Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis

Xin-Jiang Ying  1 , Pin Dong, Bin Shen, Jie Wang, Sang Wang, Guo Wang
Affiliations
Meta-Analysis

Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis

Xin-Jiang Ying et al. J Cancer Res Clin Oncol. 2011 Nov.

Abstract

Purpose: N-acetyltransferase 2 (NAT2) plays an important role in the metabolism of various potential carcinogens, which can be subdivided into rapid and slow acetylation phenotype according to the different genotypes. A number of studies have been devoted to the association of NAT2 polymorphism with susceptibility to laryngeal carcinoma; however, the results were inconsistent and inconclusive. The aim of the present study was to conduct a meta-analysis assessing the possible association of NAT2 polymorphism with laryngeal cancer risk.

Methods: The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure until February 2011 and selected on the basis of the established inclusion criteria for publications, and then a meta-analysis was performed to quantitatively summarize the association of NAT2 polymorphism with laryngeal cancer susceptibility.

Results: Seven studies were included in the present meta-analysis, which described a total of 980 laryngeal cancer cases and 1,487 controls. The overall odds ratio (OR) for NAT2 slow and rapid acetylators was 0.99 (95% CI = 0.71-1.38) and 1.01 (95% CI = 0.72-1.40), respectively. When stratifying for race, the pooled ORs for NAT2 slow acetylator were 1.99 (95% CI = 1.10-3.63) in Asians and 0.85 (95% CI = 0.62-1.15) in Caucasians, and the pooled ORs for NAT2 rapid acetylator were 0.50 (95% CI = 0.28-0.91) in Asians and 1.18 (95% CI = 0.87-1.60) in Caucasians.

Conclusions: This meta-analysis suggested that there was overall lack of association between NAT2 polymorphism and laryngeal cancer risk; however, NAT2 slow acetylation may contribute to a risk factor for laryngeal cancer in Asians but not in Caucasians.

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Conflict of interest statement

We declare that we have no conflict of interest.

Figures

Fig. 1
Fig. 1
Galbraith plot of NAT2 genotype and laryngeal cancer susceptibility
Fig. 2
Fig. 2
Meta-analysis of slow acetylators and laryngeal cancer susceptibility
Fig. 3
Fig. 3
Meta-analysis of rapid acetylators and laryngeal cancer susceptibility
Fig. 4
Fig. 4
Meta-analysis of slow acetylators and laryngeal cancer susceptibility without heterogeneity
Fig. 5
Fig. 5
Funnel plot of association between NAT2 polymorphism and laryngeal cancer
Fig. 6
Fig. 6
Begg’s funnel plot with pseudo-95% confidence limits
Fig. 7
Fig. 7
Egger’s publication bias plot
See this image and copyright information in PMC

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