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. 2011 Sep;56(5):367-72.
doi: 10.1007/s12223-011-0051-z. Epub 2011 Aug 30.

Genes of intestinal Escherichia coli and their relation to the inflammatory activity in patients with ulcerative colitis and Crohn's disease

Laura Gombošová  1 , I Lazúrová, M Zakuciová, K Curová, M Kmeťová, D Petrášová, L Siegfried
Affiliations

Genes of intestinal Escherichia coli and their relation to the inflammatory activity in patients with ulcerative colitis and Crohn's disease

Laura Gombošová et al. Folia Microbiol (Praha). 2011 Sep.

Abstract

Escherichia coli gene fimA was the most frequent gene that occurred in the intestine of all investigated groups. All subjects with fimA gene had significantly higher values of tumor necrosis factor alpha (TNF-α) and CRP than those with other E. coli genes. There was also a tendency to increased serum interleukin (IL)-6 levels in patients carrying the fimA gene; however, no relation was observed to serum IL-8 and IL-10. Patients with Crohn's disease had significantly higher IL-6 than those with ulcerative colitis (UC) and controls. The highest levels of TNF-α were detected in the UC group. There were no significant differences in serum IL-8 and IL-10 between all three groups. The presence of E. coli gene fimA in the large bowel of patients with IBD is related to the immunological activity of the disease which may be important from the aspect of therapeutical strategy.

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Figures

Fig. 1
Fig. 1
Plasma levels of IL-6, IL-8, IL-10, TNF-α, and CRP in all investigated groups in relation to the presence of most frequently occurring E. coli genes (afa, eae, cnf1, fimA); white columns negative, gray columns positive
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