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. 2011 Oct 15;92(7):722-5.
doi: 10.1097/TP.0b013e31822eec39.

African American living-kidney donors should be screened for APOL1 risk alleles

David M Cohen  1 , Anuja Mittalhenkle, David L Scott, Carlton J Young, Douglas J Norman
Affiliations

African American living-kidney donors should be screened for APOL1 risk alleles

David M Cohen et al. Transplantation. .

Abstract

The adjusted rate of end-stage kidney disease (ESKD) among African Americans is markedly increased relative to European Americans. African Americans are overrepresented on the kidney transplantation waiting list and experience longer wait times. In aggregate, these pressures drive recommendations for living donor transplantation. Genovese et al. recently implicated the APOL1 gene in ESKD risk among African Americans (Genovese et al. Science 2010; 329: 841). The presence of two APOL1 risk alleles doubles the relative risk for ESKD; moreover, the alleles are prevalent among African Americans. We propose a strategy for screening for the presence of APOL1 risk alleles among African American living kidney donors and for living-related donors for African American recipients.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. U.S. Renal Data System 2010 Annual Data Report: Atlas of chronic kidney disease and end-stage renal disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2010. p. 255. 2010.
    1. 2009 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1999–2008. Rockville, MD: U.S. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2009.
    1. Gibney EM, King AL, Maluf DG, et al. Living kidney donors requiring transplantation: Focus on African Americans. Transplantation. 2007;84:647. - PubMed
    1. Lentine KL, Schnitzler MA, Xiao H, et al. Racial variation in medical outcomes among living kidney donors. N Engl J Med. 2010;363:724. - PMC - PubMed
    1. Klag MJ, Whelton PK, Randall BL, et al. End-stage renal disease in African-American and white men. 16-year MRFIT findings. JAMA. 1997;277:1293. - PubMed

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