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Editorial
. 2011 Sep;30(9):581-4.
doi: 10.5732/cjc.011.10300.

Platelet-derived growth factor signaling in human malignancies

Kun-Wei Liu  1 , Bo Hu, Shi-Yuan Cheng
Affiliations
Editorial

Platelet-derived growth factor signaling in human malignancies

Kun-Wei Liu et al. Chin J Cancer. 2011 Sep.

Abstract

Platelet-derived growth factors (PDGFs) and their receptors were identified and purified decades ago. PDGFs are important during normal development and in human cancers. In particular, autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia. In contrast, paracrine signaling was found in cancers that originate from epithelial cells, where it may be involved in stromal cell recruitment, metastasis, and epithelial-mesenchymal transition. This editorial briefly discusses autocrine and paracrine PDGF signaling and their roles in human cancers, and introduces a series of review articles in this issue that address the possible roles of PDGFs in various processes involved in different types of cancers.

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References

    1. Ross R, Glomset J, Kariya B, et al. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro [J] Proc Natl Acad Sci USA. 1974;71(4):1207–1210. - PMC - PubMed
    1. Kohler N, Lipton A. Platelets as a source of fibroblast growth-promoting activity [J] Exp Cell Res. 1974;87(2):297–301. - PubMed
    1. Ross R, Vogel A. The platelet-derived growth factor [J] Cell. 1978;14(2):203–210. - PubMed
    1. Waterfield MD, Scrace GT, Whittle N, et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus [J] Nature. 1983;304(5921):35–39. - PubMed
    1. Doolittle RF, Hunkapiller MW, Hood LE, et al. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor [J] Science. 1983;221(4607):275–277. - PubMed

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